A two-stage learning method for protein-protein interaction prediction

In this paper, a new method for PPI (proteinprotein interaction) prediction is proposed. In PPI prediction, a reliable and sufficient number of training samples is not available, but a large number of unlabeled samples is in hand. In the proposed method, the denoising autoencoders are employed for learning robust features. The obtained robust features are used in order to train a classifier with a better performance. The experimental results demonstrate the capabilities of the proposed method. Protein-protein interaction; Denoising autoencoder; Robust features; Unlabelled data;